Dermatological Aspects of immunoglobulin G4 (IgG4)-Related Disease

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Dermatological aspects of immunoglobulin G4 (IgG4)-related disease.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease characterized by lymphoplasmacytic inflammation, fibrosis, and elevated levels of IgG4 in tissues and eventually in the blood. IgG4-RD is a recently described disease and encompasses classic entities such as Riedel’s thyroiditis, Mikulicz syndrome, and Küttner’s tumor. It is a rare disease that affects middle-aged men, especially...

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Immunoglobulin G4-Related Disease (IgG4-RD) with Associated Sarcoidosis

Immunoglobulin G-4 related disease represents a collection of tumefactive entities associated with an abundance of infiltrating IgG4 positive plasma cells, which was described first in patients with chronic pancreatitis. Since then, IgG4 related disease has been described in multiple organ systems including the orbit. We describe here a patient with a history of sarcoidosis who was subsequently...

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Esophageal Involvement of Immunoglobulin G4-Related Disease

Immunoglobulin G4 (IgG4)-related disease is characterized by the typical histopathological features of a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, a high ratio of IgG4- to IgG-positive cells, storiform fibrosis (cellular fibrosis organized in an irregular whorled pattern), obliterative phlebitis, and variable presence of eosinophils. The disease exhibits systemic in...

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Nasal manifestations of immunoglobulin G4-related disease.

OBJECTIVES/HYPOTHESIS Immunoglobulin (Ig)G4-related disease is a systemic syndrome, characterized by sclerosing lesions that mainly affect the exocrine tissue. Although some patients with IgG4-related disease complain of nasal symptoms, there are few reports concerning the nasal manifestations of this disease. We investigated the clinical and pathological features of the nasal manifestations of...

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Immunoglobulin G4-related disease (IgG4-RD) affecting the esophagus, stomach, and liver.

A 60-year-old man, with occasional acid reflux, was found on computed tomography (CT) to have multiple masses in his esophagus (●" Fig.1a), stomach (●" Fig.1 d), and liver. He had a history of partial hepatectomy for inflammatory liver pseudotumor on two occasions, 22 and 9 years earlier. Physical examination revealed no superficial lymph node. Blood test showed that hemoglobin was 105g/L, and ...

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ژورنال

عنوان ژورنال: Actas Dermo-Sifiliográficas (English Edition)

سال: 2015

ISSN: 1578-2190

DOI: 10.1016/j.adengl.2015.01.010